Of America’a largest metro areas, cities with the lowest percentage of Hispanic residents are Jackson Mississippi 1.2% hispanic, Warren Michigan at 2.1% and Akron Ohio at 2.3%. Most Spanish- speaking cities in U.S. US now has more Spanish speakers than Spain – only Mexico has more. Only two of Spain’s cities, the national capital Madrid and Barcelona, have populations of more than one million. The smallest country is Equatorial Guinea with around 740,000 (2013). The Quebecois city had a great claim to fame – it was the second largest Francophone city in the world after Paris, the capital of the Mother Country. Of course, there are many cities in America with a 0% hispanic population. Buenos Aires, Argentina. The city of Douala might be the most unknown city on this list. Lima, Peru. Some 15.5 million people, or 38.3 per cent of Spain’s population of 40.5 million, live in the country’s 50 largest cities. Published on December 20, 2004. READ THIS NEXT How restaurant chains are duking it out to be the best in their categories. Madrid, Spain. Bogotá, Colombia. Not to mention the fact that Spanish is continuing to grow in traditionally non-Spanish speaking countries. Booming populations in French-speaking Africa have changed the game. Mexico City, Mexico. The following information relates to areas within the cities' municipal borders, not their metropolitan areas, and notes the percentage and number of people age five or older who speak Spanish at home in several of the largest U.S. cities. Authorities say the shooter is a 21-year-old white male who may have circulated an anti-immigrant manifesto hours before the attack. Spanish has no official recognition in the Central American nation of Belize, a Commonwealth realm where English is the official national language. The largest Spanish-speaking country in the world, referring to population size, is Mexico with over 118 million people (2013). Let’s take the United States, for example, where Hispanics account for 18% of America’s population, and are projected to make up 28% by 2060, according to the United States Census Bureau. Still, it is the largest city in Cameroon and has a Francophone population of 2,446,945 people. The city is known to be the economic capital of Cameroon and its surrounding region, and it has the largest port in all of Central Africa. Spanish Speaking Places. What is the largest Spanish speaking country in the world? Not any more. El Paso, the Texas city that was the site of a mass shooting at a Walmart this weekend, is one of the largest hubs for Latino and Hispanic people in the country.. The 50 largest Spanish cities. Caracas, Venezuela. Spanish as a Former Official Language. Barcelona, Spain. Santiago de Chile, Chile. Cities proper. 10 Largest Spanish Speaking Countries and Their Cities. 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